Biosketch

David B. Sacks received his medical training at the University of Cape Town, South Africa. He completed residencies in Internal Medicine at Georgetown University affiliated hospitals in Washington, D.C. and in Clinical Pathology at Washington University School of Medicine in St. Louis and is board certified in both disciplines. After completing fellowship training in Clinical Chemistry at Washington University School of Medicine, he joined the Department of Pathology at Harvard Medical School and Brigham and Women's Hospital, where he was both Medical Director of Clinical Chemistry and Director of the Clinical Pathology Training Program. He joined the NIH as Chief of Clinical Chemistry in 2011.

The scientific work in his research laboratory is in the general area of intracellular signal transduction, with a focus on calcium and calmodulin signaling. His research has been funded for over 20 years by grants from the National Institutes of Health, the American Diabetes Association, the Diabetes Action Research and Education Foundation, the Susan G. Komen Breast Cancer Foundation, the U.S. Army and the Burroughs Wellcome Fund.

Dr. Sacks's primary clinical focus is in diabetes mellitus, with an emphasis on the interface between the clinical laboratory and patient care. In this endeavor, he has worked closely with the American Diabetes Association. He is Chair of the National Glycohemoglobin Standardization Program (NGSP) steering committee. He was Director of the Young Investigator Program of the Academy of Clinical Laboratory Physicians and Scientists (ACLPS) from 1995-2001 and later served as President of ACLPS. In addition, he serves on or chairs several other national and international committees. He was elected a Fellow of the Royal College of Pathologists in 1998.

Dr. Sacks has published more than 150 articles in scientific journals. He has served on the editorial board of Clinical Chemistry since 1995 and is currently an Associate Editor of the journal. In addition, he has served on several other editorial boards, including The Journal of Biological Chemistry, The American Journal of Pathology and The American Journal of Clinical Pathology and is a member of the editorial advisory panel of The Biochemical Journal.

Honors and Awards

Distinguished Scientist Award, National Academy of Clinical Biochemistry, 2009; Gerald T. Evans Award, Academy of Clinical Laboratory Physicians and Scientists, 2008; Visiting Professor, South African Association of Clinical Biochemists, 2007; Transatlantic Award Lecture, The Association for Clinical Biochemistry, 2007; Norman P. Kubasik Lectureship Award, American Association for Clinical Chemistry, Upstate New York Section, 2006; Outstanding Contributions to Clinical Chemistry in a Selected Area of Research, American Association for Clinical Chemistry, 2005; Visiting Professor, Royal College of Pathologists of Australasia, 2003; Lilian B. Ladenson and Oree M. Caroll Visiting Professor, Washington University School of Medicine, 1998.

Selected Publications

ORIGINAL REPORTS

Li L, Li Z, Sacks DB. The transcriptional activity of estrogen receptor-α is dependent on Ca²⁺/calmodulin. J Biol Chem 2005; 280:13097-13104.

Li Z, McNulty DE, Marler KJM, Lim L, Hall C, Annan RS, Sacks DB. IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. J Biol Chem 2005; 280:13871-13878.

Ren JG, Li Z, Crimmins DL, Sacks DB. Self association of IQGAP1: Characterization and functional sequelae. J Biol Chem 2005; 280:34548-34557.

Roy M, Li Z, Sacks DB. IQGAP1 is a scaffold for mitogen-activated protein kinase signaling. Mol Cell Biol 2005; 25:7940-7952.

Li L, Li Z, Howley PM, Sacks DB. E6AP and calmodulin reciprocally regulate estrogen receptor stability. J Biol Chem 2006; 281:1978-1985.

Ren JG, Li Z, Sacks DB. IQGAP1 modulates activation of B-Raf. Proc Natl Acad Sci USA 2007; 104:10465-10469.

Jeong HW, Li Z, Brown MD, Sacks DB. IQGAP1 binds Rap1 and modulates its activity. J Biol Chem 2007; 282:20752-20762.

Brown MD, Bry L, Li Z, Sacks DB. IQGAP1 regulates Salmonella invasion through interactions with actin, Rac1 and Cdc42. J Biol Chem 2007; 282:30265-30272.

Jadeski L, Mataraza JM, Jeong HW, Li Z, Sacks DB. IQGAP1 stimulates proliferation and enhances tumourigenesis of human breast epithelial cells. J Biol Chem 2008; 283:1008-1017.

Owen D, Campbell LJ, Littlefield K, Evetts KA, Li Z, Sacks DB, Lowe PN, Mott HR. The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes. J Biol Chem 2008; 283:1692-1704.

Ren JG, Li Z, Sacks DB. IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling. J Biol Chem 2008; 283:22972-22982.

Brown MD, Bry L, Li Z, Sacks DB. Actin pedestal formation by EPEC is regulated by IQGAP1, calcium and calmodulin. J Biol Chem 2008; 283: 35212-35222.

McNulty DE, Li Z, White CD, Sacks DB, Annan RS. MAP kinase scaffold IQGAP1 binds the EGF receptor and modulates its activation. J Biol Chem 2011; 286:15010-15021.

Sacks DB, Arnold M, Bakris GL, Bruns DE, Horvath AR, Kirkman MS, Lernmark A, Metzger BE, Nathan, DM. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem 2011, in the press.

BOOK CHAPTERS/REVIEWS

Brown MD, Sacks DB. IQGAP1 in cellular signalling: bridging the GAP [Review]. Trends Cell Biol 2006; 16:242-249.

Brown MD, Sacks DB. Compartmentalized MAPK pathways. In: Scott JD, Klussmann E, editors. Handbook of Experimental Pharmacology. Amsterdam: Springer, 2008; 186:205-235.

Scott MG, Bruns DE, Boyd JC, Sacks DB. Tight glucose control in the intensive care unit: are glucose meters up to the task? Clin Chem 2009; 55:18-20.

Little RR, Sacks DB. HbA1c: How do we measure it and what does it mean? [Review]. Curr Opin Endocrinol Diabetes Obes 2009; 16:113-118.

Sacks DB. Intensive glucose control in the ICU: Is SUGAR NICE? Nat Rev Endocrinol 2009; 5:473-474.

White CD, Brown MD, Sacks DB. IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis [Review]. FEBS Lett 2009; 583:1817-1824.

Little RR, Rohlfing CL, Sacks DB. Status of HbA1c measurement and goals for improvement: From chaos to order for improving diabetes care [Review]. Clin Chem 2011; 57:204-214.

Sacks DB. A1c versus glucose testing: A comparison [Review]. Diabetes Care 2011; 518-523.

Kim H, White CD, Sacks DB. IQGAP1 in microbial pathogenesis: Targeting the actin cytoskeleton [Review]. FEBS Lett 2011; 585:723-729.

Sacks DB. Carbohydrates. In: Burtis CA, Ashwood ER, Bruns DE, editors. Tietz textbook of clinical chemistry and molecular diagnostics. 5th ed. St. Louis: Elsevier Saunders, 2011, in press.

Sacks DB. Diabetes mellitus. In: Burtis CA, Ashwood ER, Bruns DE, editors. Tietz textbook of clinical chemistry and molecular diagnostics. 5th ed. St. Louis: Elsevier Saunders, 2011, in press.